Essential mixed cryoglobulinemia (EMC)

is a rare autoimmune disorder that affects the blood and various other body systems. Patients with EMC have a mixture of various types of antibodies (cryoglobulins) in the blood. Major symptoms may include unusual response to cold, skin abnormalities, weakness and blood problems. There may also be joint pain, inflamed blood vessels, and kidney problems

EMC is one of three conditions associated with Cryoglobulinemia. Cryoglobulinemia is the presence of abnormal proteins in the blood. These abnormal proteins become thick or gel‐like in cold temperatures. Cryoglobulins differ from normal immunoglobulins (antibodies formed by cells of the immune system) because they precipitate at cold conditions but dissolve again when warmed It is not known how or why these cryoglobulins are formed.

Essential mixed cryoglobulinemia is not usually apparent until middle age and affects females more often than males.

Symptoms of Essential mixed cryoglobulinemia

  • Progressive deterioration of kidney function
  • Blood in urine
  • Edema
  • Extreme response to cold, such as loss of feeling in hands or feet
  • Skin abnormalities
  • Weakness
  • Blood problems
  • Joint pain
  • Inflamed blood vessels
  • Joint swelling
  • Abdominal pain
  • Weight loss or poor appetite
  • Enlarged spleen


For general information or to schedule an appointment, call 212.305.4308. You may need a doctor's referral; please consult with your insurance provider prior to your appointment to ensure your visit will be covered under your policy.

Your appointment

  • To prepare for your appointment, make a list of all prescription and over-the-counter medications you take. Include the dosage and frequency with which you take them. Please bring the list with you to your appointment.
  • First-time office consultations typically require an hour long appointment.
  • Please arrive 15 minutes prior to your scheduled appointment for registration.
  • It is not necessary to fast for your first visit, unless you are instructed to do so by the doctor.
  • If you are not a current Columbia/NYP patient, please bring your outside medical records with you or ask your doctor to fax them to us at 212.342.6835.
  • A brief medication information form will need to be completed at each visit.
  - Access Your Health Record Information
  - Request an Appointment
  - Renew a Prescription
  - Ask Questions
  - Receive Appointment Reminderscurrent

  - Please Note: version of the Patient Portal is only compatible with Google Chrome and Firefox