Columbia Rheumatology Genetics Clinic

The CUIMC/NY-Presbyterian Rheumatology Genetics Clinic, led by Dr. Yiming Luo, specializes in evaluating patients with immune-mediated conditions with highly unusual clinical presentations. This includes cases with features of autoinflammation (including fever of unknown origin), atypical autoimmune disease overlaps, and immunodeficiency.

The clinic offers cutting-edge genetic testing to identify potential rare monogenic causes (scenarios where a single genetic defect makes a major contribution to the illness) underlying these complex conditions. A hallmark of this clinic is its expertise in independently interpreting genetic testing results, integrating each patient's unique clinical context with advanced knowledge of molecular genetics.

Through collaborations with the Department of Medicine Center for Precision Medicine and Genomics (CPMG) and the New York Regional Inborn Errors of Immunity Resource Initiative League (NY ROYAL), the clinic offers genetic counseling, specialized assays for specific findings, and opportunities to participate in pioneering research studies. This multifaceted approach ensures patients with challenging immunological conditions or diagnostic uncertainties receive state-of-the-art diagnostic evaluations and potential therapeutic interventions tailored to their genetic underpinnings. 

ColumbiaDoctors Rheumatology & Clinical Immunology is a leader in the care and treatment of rheumatic disease, offering the latest therapies for patients of all ages. Many of our treatment services are also offered through participation in research studies.

Call (212) 305-4308 for an appointment or referral!