RA and PsA STUDIES


TARGET:

Treatments Against RA and Effect on FDG PET-CT: The TARGET Trial: TARGET is a multi-center, randomized clinical trial aimed at understanding how different treatments for rheumatoid arthritis affect vascular inflammation.  Subjects who are inadequate responders to methotrexate monotherapy will be randomized to one of two types of DMARD therapy, either a TNF-inhibitor plus methotrexate or Trial Therapy (sulfasalazine, hydroxychloroquine, and methotrexate). Participation in this trial lasts 6 months.

PsA  Adipose Study: Title: Psoriatic Arthritis FAT Aspiration
The purpose of this research study is to compare adipose (body fat) inflammation and characteristics between patients with Psoriatic Arthritis (PsA), Rheumatoid Arthritis (RA), and controls (without rheumatic diseases).


RHYTHM (formerly called Escape II Myocardium): the RHeumatoid arthritis studY of THe Myocardium. The purpose of this study is to investigate how and why rheumatoid arthritis may adversely affect the heart muscle, and whether certain medications can protect the heart from such an effect.


Long Term Follow Up Study: Title: RHYTHM (the RHeumatoid arthritis studY of THe Myocardium) Long Term Follow-up. participants who participated in the parent study (RHYTHM formerly called ESCAPE II Myocardium) to return 3-5 years post-baseline for a repeat CAC measurement to evaluate whether those with higher baseline levels of vascular inflammation, measured by vascular FDG PET/CT during their initial study visit, compared to those with lower levels, are at higher risk for progression of coronary atherosclerosis.


RA PIM Study Title: Bone Marrow and Blood Collection in Subjects with Rheumatoid Arthritis and Healthy Control Subjects to Study Causes of Autoimmunity The purpose of this research study is to study the abnormalities in cells of the immune (protective) system of patients with rheumatoid arthritis. These immune cells come from the bone marrow (the soft center of a bone, where blood cells are created). We plan to give your bone marrow cells to mice, in which cells of the immune system will develop from your bone marrow cells. This will allow us to  create an immune system in a mouse that is the same as your immune system before you had rheumatoid arthritis. By doing this, we will be able to study the processes that came before you  developed rheumatoid arthritis. We will also be able to study the genetic factors that contribute to developing rheumatoid arthritis.


REASON study: Title: RhEumatoid Arthritis Synovial Network:

To examine the factors present in the cells from the inflamed joint of patients that may cause rheumatoid arthritis, in order to develop new treatments.

Interested in Participating
  • Participating in Research

    If you are interested in participating in any of our research trials, please contact:
    Afshin Zartoshti at az2200@columbia.edu
    Phone: 212-342-2751