Mor Lab

Our Research

Researcher looking into microscope

Uncovering the Biology Behind Programmed Cell Death 1 (PD-1)

One of our lab’s major ongoing research projects is uncovering the biology of PD-1 and LAG3 in exhausted T cells.
A summary of all the proteins that we discovered to regulate PD-1 signaling and function.

Discover and Develop Novel Checkpoint Inhibitors

Using high-resolution proteomic approaches, we have uncovered targetable signaling proteins downstream of PD-1 as well as novel checkpoints that are highly expressed on tumor-infiltrating lymphocytes.
Schematic showing model of targeting PAG using anti-PAG antibodies.

Determine the Mechanism Behind Immune-Related Adverse Events Associated with Checkpoint Inhibitors

We study the ways in which PD-1 blockade reshape homeostatic T cell responses, making use of single-cell RNA sequencing.
Immune checkpoint inhibitors can lead to the development of inflammation in many organs. The treatment of tumors with anti-PD-1 or anti-PD-L1 antibodies increases the activation of tumor infiltrating cytotoxic T cells and leads to tumor cell death. These

Target T Cell Adhesion and Migration in Autoimmunity

Our work includes a functional inhibitory RNA screen to identify signaling mediators downstream of CXCR4 within human T cells and discovering a novel role for PLCe1 in recruitment of T cells.
Chemokines direct the movement of T cells from circulation into tissues. T cells in circulation roll along the endothelium until chemokine receptors are engaged leading to arrest and firm adhesion before diapedesis into the tissue. Previous therapeutic in